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Strain Detail


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 Strain information
  CARD ID
588 
Type of strain Targeted mutant. 
Strain name ICR;129S4-Pargtm1Ncc/Csk 
Internal Code
ICR;129S4-Pargtm1Ncc/Csk 
Submitter Unknown Unknown 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Chugai Research Institute for Medical Science Inc., National Cancer Center Research Institute 
Organization code Csk, Ncc 
Developer Kou-ichi Jishage, Mitsuko Masutani 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Parg 
Gene name Poly (ADP-ribose) glycohydrolase 
Allele symbol Pargtm1Ncc 
Allele name Parg,National Cancer Center Research Institute 
MGI MGI:1347094 
Chromosome 14  
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
OMIM OMIM ID: 603501
Human Gene Symbol: PARG

 

 Reference information
 reference information 1
  Author
Atsushi Shibata, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani 
Title Parp-1 deficiency causes an increase of deletion mutations and insertions/ rearrangements in vivo after treatment with an alkylating agent 
Journal Oncogene 
Volume 24 
Page 1328-1337 
Year 2005 
PMID 15608683  
 
 reference information 2
  Author
MITSUKO MASUTANI, HIROSHI SUZUKI, NOBUO KAMADA, MIHO WATANABE, OTOYA UEDA, TADASHIGE NOZAKI, KOU-ICHI JISHAGE, TAKESHI WATANABE, TETSURO SUGIMOTO, HITOSHI NAKAGAMA, TAKAHIRO OCHIYA, AND TAKASHI SUGIMURA 
Title Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes 
Journal Proc. Natl. Acad. Sci. USA 
Volume 96 
Page 2301-2304 
Year 1999 
PMID 10051636  
 
 reference information 3
  Author
T. Nohmi, M. Katoh, H. Suzuki, M. Matsui, M. Yamada, M. Watanabe, M. Suzuki, N. Horiya, O. Ueda, T. Shibuya, H. Ikeda, and T. Sofuni 
Title A NewTransgenic Mouse Mutagenesis Test System Using Spi- and 6-Thioguanine Selections 
Journal Environmental and Molecular Mutagenesis 
Volume 28 
Page 465-470 
Year 1996 
PMID 8991079  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Metabolism, Immunology 
  OMIM OMIM ID: 603501
Human Gene Symbol: PARG