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Strain Detail


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 Strain information
  CARD ID
579 
Type of strain Targeted mutant. 
Strain name ICR;129S4-Parp1tm1Hsmm/Hsmm 
Internal Code
ICR;129S4-Parp1tm1Hsmm/Hsmm 
Submitter Unknown Unknown 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Chugai Pharmaceutical Co. Ltd., National Cancer Center Research Institute 
Organization code Csk, Ncc 
Developer Hiroshi Suzuki, Mitsuko Masutani 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Parp1 
Gene name Poly (ADP-ribose) polymerase family, member 1 
Allele symbol Parp1tm1Hsmm 
Allele name Parp1,National Cancer Center Research Institute 
MGI MGI:1340806 
Chromosome 1 (98.6) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
OMIM OMIM ID: 173870
Human Gene Symbol: PARP1

 
 Primer 1
  PCR Primer Kato-P-1  5'-gcgcaacctattttcccctcgaa-3' 
Kato-P-2  5'-ctggaaactattgtaacccgcctg-3' 
 

 Reference information
 reference information 1
  Author
Atsushi Shibata, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani 
Title Parp-1 deficiency causes an increase of deletion mutations and insertions/ rearrangements in vivo after treatment with an alkylating agent 
Journal Oncogene 
Volume 24 
Page 1328-1337 
Year 2005 
PMID 15608683  
 
 reference information 2
  Author
MITSUKO MASUTANI, HIROSHI SUZUKI, NOBUO KAMADA, MIHO WATANABE, OTOYA UEDA, TADASHIGE NOZAKI, KOU-ICHI JISHAGE, TAKESHI WATANABE, TETSURO SUGIMOTO, HITOSHI NAKAGAMA, TAKAHIRO OCHIYA, AND TAKASHI SUGIMURA 
Title Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes 
Journal Proc. Natl. Acad. Sci. USA 
Volume 96 
Page 2301-2304 
Year 1999 
PMID 10051636  
 
 reference information 3
  Author
T. Nohmi, M. Katoh, H. Suzuki, M. Matsui, M. Yamada, M. Watanabe, M. Suzuki, N. Horiya, O. Ueda, T. Shibuya, H. Ikeda, and T. Sofuni 
Title A NewTransgenic Mouse Mutagenesis Test System Using Spi- and 6-Thioguanine Selections 
Journal Environmental and Molecular Mutagenesis 
Volume 28 
Page 465-470 
Year 1996 
PMID 8991079  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Metabolism, Neurobiology, cancer, Immunology, Physiology 
  OMIM OMIM ID: 173870
Human Gene Symbol: PARP1