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Strain Detail


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 Strain information
  CARD ID
571 
Type of strain Transgenic. 
Strain name C57BL/6-Tg(CLCNKB-WNK4D564A 
Internal Code mutant WNK4 transgenic mice
C57BL/6-Tg(CLCNKB-WNK4564A 
Submitter Unknown Unknown 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Tokyo Medical & Dental University 
Organization code none 
Developer Uchida Shinichi 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
WNK4 
Gene name human WNK4 (lysine deficient protein kinase 4), D564A(Aan aspartic acid-to-alanine substitution at codon 564) 
Allele symbol  
Allele name  
MGI  
Chromosome Unknown  
Gene classification Gene to express(transgenic) 
Method MicroInjection 
OMIM OMIM ID: 601844
Human Gene Symbol: WNK4

 
 Primer 1
  PCR Primer hWNK4seqPr2(tg-se)  5'-ATC GTC CGC TTC TAT GAT TC-3' 
hWNK4R(tg-an)  5'-TCG CAC TTG AGA TCC CGG TG-3' 
 

 Reference information
 reference information 1
  Author
Kozue Yamauchi, Sung-Sen Yang, Akihito Ohta, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida 
Title Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice 
Journal Biochemical and Biophysical Research Communications 
Volume 332 
Page 750-755 
Year 2005 
PMID 15907795  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Physiology 
  OMIM OMIM ID: 601844
Human Gene Symbol: WNK4
Allelic Variant Name :
PSEUDOHYPOALDOSTERONISM, TYPE IIB