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Strain Detail


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 Strain information
  CARD ID
533 
Type of strain Targeted mutant. 
Strain name D2.129-Chrm2tm1 
Internal Code 2ND
D2.129-Chrm2tm1 
Submitter Unknown Unknown 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions Other conditions. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Graduate Sch. Pharm. Sci., Univ. Tokyo 
Organization code  
Developer MATSUI Minoru 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Chrm2 
Gene name cholinergic receptor, muscarinic 2, cardiac 
Allele symbol Chrm2tm1 
Allele name targeted mutation 1 
MGI MGI:88397 
Chromosome 6 (syntenic ) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
GO
GO ID GO Term GO Evidence Code
GO:0004930 G-protein coupled receptor activity IEA
GO:0016021 integral to membrane IEA
GO:0016020 membrane IEA
GO:0045211 postsynaptic membrane IEA
GO:0004872 receptor activity IEA
GO:0004871 signal transducer activity IEA
GO:0005886 plasma membrane IEA
GO:0045202 synapse IEA
GO:0007186 G-protein coupled receptor protein signaling pathway IEA
GO:0030054 cell junction IEA
more... (Total Hit Count: 13)
OMIM OMIM ID: 118493
Human Gene Symbol: CHRM2

GO
GO ID GO Term GO Evidence Code
GO:0004930 G-protein coupled receptor activity IEA
GO:0016021 integral to membrane IEA
GO:0016020 membrane IEA
GO:0045211 postsynaptic membrane IEA
GO:0004872 receptor activity IEA
GO:0004871 signal transducer activity IEA
GO:0005886 plasma membrane IEA
GO:0045202 synapse IEA
GO:0007186 G-protein coupled receptor protein signaling pathway IEA
GO:0030054 cell junction IEA
more... (Total Hit Count: 13)
 

 Reference information
 reference information 1
  Author
Hiroshi Karasawa, Makoto M. Taketo, Minoru Matsui 
Title Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4 
Journal European Journal of Pharmacology 
Volume 468 
Page 15-19 
Year 2003 
PMID 12729838  
 
 reference information 2
  Author
Minoru Matsui, Daisuke Motomura, Hiroshi Karasawa, Toru Fujikawa, Jian Jiang, Yuriko Komiya, Shin-ichi Takahashi, and Makoto M. Taketo 
Title Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype 
Journal PNAS 
Volume 97 
Page 9579-9584 
Year 2000 
PMID 10944224  
 
 reference information 3
  Author
Minoru Matsui, Daisuke Motomura, Toru Fujikawa, Jian Jiang, Shin-ichi Takahashi, Toshiya Manabe, and Makoto M. Taketo 
Title Mice Lacking M2 and M3 Muscarinic Acetylcholine Receptors Are Devoid of Cholinergic Smooth Muscle Contractions But Still Viable 
Journal The Journal of Neuroscience 
Volume 22 
Page 10627-10632 
Year 2002 
PMID 12486155  
 
 reference information 4
  Author
Takako Ohno-Shosaku, Minoru Matsui, Yuko Fukudome, Jumpei Shosaku, Hiroshi Tsubokawa, Makoto M. Taketo, Toshiya Manabe and Masanobu Kano 
Title Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus 
Journal European Journal of Neuroscience 
Volume 18 
Page 109-116 
Year 2003 
PMID 12859343  
 
 reference information 5
  Author
Takeshi Nakamura, Minoru Matsui, Keiko Uchida, Akira Futatsugi, Shinji Kusakawa, Nagisa Matsumoto, Kyoko Nakamura, Toshiya Manabe, Makoto M. Taketo and Katsuhiko Mikoshiba 
Title M3 muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice 
Journal J Physiol 
Volume 558 
Page 561-575 
Year 2004 
PMID 15146045  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Metabolism, Neurobiology, Dermatology, cancer, Immunology, Development, Anatomy, Physiology 
  OMIM OMIM ID: 118493
Human Gene Symbol: CHRM2