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Strain Detail


 - Strains   - Genes   - Disease,Applicable field 
 Strain information
  CARD ID
332 
Type of strain Transgenic. 
Strain name C57BL/6-Apoetm1 Tg(Edn1-bLOX1) 
Internal Code C57BL/6-apoE-/-.Tg(ET-BLOX)1
C57BL/6-Apoetm1 Tg(Edn1-bLOX1) 
Submitter Tatsuya Sawamura 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Department of Bioscience, National Cardiovascular Center Research Institute 
Organization code  
Developer Tatsuya Sawamura, Yuji Arai 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Apoe 
Gene name apolipoprotein E 
Allele symbol Apoetm1 
Allele name targeted mutation 1 
MGI MGI:88057 
Chromosome 7  
Gene classification Gene to express(transgenic) 
Method MicroInjection 
OMIM OMIM ID: 107741
Human Gene Symbol: APOE

 
 Gene information 2
  Gene symbol
Apoe 
Gene name  
Allele symbol Tg(Edn1-bLOX1) 
Allele name transgene 
MGI MGI:88057 
Chromosome Unknown  
Gene classification Gene to express(transgenic) 
Method MicroInjection 
OMIM OMIM ID: 107741
Human Gene Symbol: APOE

 
 Primer 1
  PCR Primer primerA  5'(gcggc,cgcga,aaatg,actgt,tgatg,acccc)3' 
primerB  5'(gcggc,cgcaa,attca,ctgtg,ctctc,aatag)3' 
 

 Disease , Applicable field information
  Disease name,
Applicable field
Metabolism, Immunology, Physiology 
  OMIM OMIM ID: 107741
Human Gene Symbol: APOE
Allelic Variant Name :
SEA-BLUE HISTIOCYTE DISEASE
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE DEFICIENCY, AUTOSOMAL
ALZHEIMER DISEASE 2
APOE3(-)-FREIBURG
APOE4 VARIANT
HYPERLIPOPROTEINEMIA, TYPE III, DUE TO APOE4-PHILADELPHIA
APOE3 ISOFORM
HYPERCHOLESTEROLEMIA AND HYPERTRIGLYCERIDEMIA, TYPE III
APOE2 VARIANT
LIPOPROTEIN GLOMERULOPATHY
MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE DEFICIENCY
APOE2-DUNEDIN
APOE4(-)-FREIBURG
APOE4(+)
HYPERLIPOPROTEINEMIA, TYPE III, DUE TO APOE1-HARRISBURG
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE2
APOLIPOPROTEINEMIA E1
HYPERLIPOPROTEINEMIA, TYPE III
DYSBETALIPOPROTEINEMIA DUE TO APOE2
HYPERLIPOPROTEINEMIA, TYPE III, AUTOSOMAL DOMINANT
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE LEIDEN
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE7
HYPERLIPOPROTEINEMIA, TYPE III, DUE TO APOE2-CHRISTCHURCH
HYPERLIPOPROTEINEMIA AND ATHEROSCLEROSIS ASSOCIATED WITH APOE5
APOE2 ISOFORMS
APOE3 VARIANT
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE4
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE2-FUKUOKA

OMIM ID: 107741
Human Gene Symbol: APOE
Allelic Variant Name :
APOE4(+)
APOE4(-)-FREIBURG
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE DEFICIENCY, AUTOSOMAL
ALZHEIMER DISEASE 2
APOE3(-)-FREIBURG
APOE4 VARIANT
HYPERLIPOPROTEINEMIA, TYPE III, DUE TO APOE4-PHILADELPHIA
APOE3 ISOFORM
HYPERCHOLESTEROLEMIA AND HYPERTRIGLYCERIDEMIA, TYPE III
APOE2-DUNEDIN
LIPOPROTEIN GLOMERULOPATHY
HYPERLIPOPROTEINEMIA, TYPE III
MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO
SEA-BLUE HISTIOCYTE DISEASE
APOE2 VARIANT
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE DEFICIENCY
APOLIPOPROTEINEMIA E1
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE2-FUKUOKA
HYPERLIPOPROTEINEMIA, TYPE III, DUE TO APOE1-HARRISBURG
DYSBETALIPOPROTEINEMIA DUE TO APOE2
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE LEIDEN
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE7
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE2
HYPERLIPOPROTEINEMIA, TYPE III, DUE TO APOE2-CHRISTCHURCH
HYPERLIPOPROTEINEMIA AND ATHEROSCLEROSIS ASSOCIATED WITH APOE5
APOE2 ISOFORMS
APOE3 VARIANT
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE4
HYPERLIPOPROTEINEMIA, TYPE III, AUTOSOMAL DOMINANT