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Strain Detail

 - Strains   - Genes   - Disease,Applicable field 
 Strain information
  CARD ID
 288 
Type of strain Transgenic. 
Strain name BALB/cAJcl-Il2rgtm1Tg(Il2rg)M2 
Internal Code IL-2Rg M2 mutant transgenic
 
Submitter Unknown Unknown 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)		 Organization Dent. Immunology, Grad School of Med. University of Tokyo 
Organization code  
Developer Shiho Tsujino, Tadatsugu Taniguchi, et.al. 
Origin
(From other organizations)		 Organization Dept. Immunology Grad. Sch. of Medicine, Univ. of Tokyo 
Organization code  
Developer  
Year introduced  
Introduced 
Generation		  
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
 Il2rg 
Gene name Interleukin 2 receptor, gamma chain 
Allele symbol Il2rgtm1 
Allele name Il2rg, targeted mutation 1 
MGI MGI:96551 
Chromosome X  
Gene classification Gene to express(transgenic) 
Method  
GO
GO ID GO Term GO Evidence Code
GO:0016021 integral to membrane IEA
GO:0016020 membrane IEA
GO:0004872 receptor activity IEA
GO:0004896 cytokine receptor activity IEA
GO:0019976 interleukin-2 binding IPI
GO:0009897 external side of plasma membrane IDA
GO:0033089 positive regulation of T cell differentiation in the thymus IMP
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
GO:0045579 positive regulation of B cell differentiation IMP
GO:0010468 regulation of gene expression IMP
OMIM OMIM ID: 308380
Human Gene Symbol: IL2RG

GO
GO ID GO Term GO Evidence Code
GO:0016021 integral to membrane IEA
GO:0016020 membrane IEA
GO:0004872 receptor activity IEA
GO:0004896 cytokine receptor activity IEA
GO:0019976 interleukin-2 binding IPI
GO:0009897 external side of plasma membrane IDA
GO:0033089 positive regulation of T cell differentiation in the thymus IMP
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
GO:0045579 positive regulation of B cell differentiation IMP
GO:0010468 regulation of gene expression IMP
 
 Gene information 2
  Gene symbol
 Il2rgM2 
Gene name Interleukin 2 receptor, gamma chain M2(Mutation 2) (Mouse) 
Allele symbol  
Allele name  
MGI MGI:96551 
Chromosome Unknown  
Gene classification Gene to express(transgenic) 
Method  
GO
GO ID GO Term GO Evidence Code
GO:0016021 integral to membrane IEA
GO:0016020 membrane IEA
GO:0004872 receptor activity IEA
GO:0004896 cytokine receptor activity IEA
GO:0019976 interleukin-2 binding IPI
GO:0009897 external side of plasma membrane IDA
GO:0033089 positive regulation of T cell differentiation in the thymus IMP
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
GO:0045579 positive regulation of B cell differentiation IMP
GO:0010468 regulation of gene expression IMP
OMIM OMIM ID: 308380
Human Gene Symbol: IL2RG

GO
GO ID GO Term GO Evidence Code
GO:0016021 integral to membrane IEA
GO:0016020 membrane IEA
GO:0004872 receptor activity IEA
GO:0004896 cytokine receptor activity IEA
GO:0019976 interleukin-2 binding IPI
GO:0009897 external side of plasma membrane IDA
GO:0033089 positive regulation of T cell differentiation in the thymus IMP
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
GO:0045579 positive regulation of B cell differentiation IMP
GO:0010468 regulation of gene expression IMP
 

 Disease , Applicable field information
  Disease name,
Applicable field
Immunology 
  OMIM OMIM ID: 308380
Human Gene Symbol: IL2RG
Allelic Variant Name :
•
COMBINED IMMUNODEFICIENCY, X-LINKED
•
SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED

OMIM ID: 308380
Human Gene Symbol: IL2RG
Allelic Variant Name :
•
COMBINED IMMUNODEFICIENCY, X-LINKED
•
SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED

 
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