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Strain Detail


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 Strain information
  CARD ID
245 
Type of strain Transgenic. 
Strain name C57BL/6-Tg(6.0hTTRMet30)15Imeg 
Internal Code
 
Submitter Ken-ichi YAMAMURA 
Submitter affiliation or code Center for Animal Resources and Development Kumamoto University 
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Institute of Molecular Embryology and Genetics, Kumamoto Univ. 
Organization code IMEG 
Developer Ken-ichi Yamamura 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Ttr 
Gene name Transthyretin Val30Met(Human) 
Allele symbol  
Allele name  
MGI MGI:98865 
Chromosome Unknown  
Gene classification Gene to express(transgenic) 
Method  
GO
GO ID GO Term GO Evidence Code
GO:0005179 hormone activity IEA
GO:0005576 extracellular region IEA
GO:0006810 transport IEA
OMIM OMIM ID: 176300
Human Gene Symbol: TTR

GO
GO ID GO Term GO Evidence Code
GO:0005179 hormone activity IEA
GO:0005576 extracellular region IEA
GO:0006810 transport IEA
 
 Primer 1
  PCR Primer primerA  5'(TCT CAC GTG TCT TCT CTACA)3' 
primerB  3'(AGC CTC TCT CTA CCA AGTGA)5' 
 

 Reference information
 reference information 1
  Author
Yasushi Nagata, Fumi Tashiro, Shigehiro Yi, Tatsuhumi Murakami, Shuichiro Maeda, Kiyoshi Takahashi, Kazunori Shimada, Hitoshi Okamura, and Ken-ichi Yamamura 
Title A 6-kb Upstream Region of the Human Transthyretin Gene Can Direct Developmental, Tissue-Specific, and Quantitatively Normal Expression in Transgenic Mouse 
Journal J. Biochem. 
Volume 117 
Page 169-175 
Year 1995 
PMID 7775385  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Metabolism 
  OMIM OMIM ID: 176300
Human Gene Symbol: TTR
Allelic Variant Name :
TRANSTHYRETIN POLYMORPHISM
AMYLOID POLYNEUROPATHY, JEWISH TYPE
AMYLOID POLYNEUROPATHY
HYPERTHYROXINEMIA, FAMILIAL DYSPREALBUMINEMIC EUTHYROID
TRANSTHYRETIN ACIDIC ASN-90 VARIANT
AMYLOIDOSIS, LEPTOMENINGEAL
AMYLOID CARDIOMYOPATHY
AMYLOIDOSIS, CARDIAC OR DENMARK TYPE
TRANSTHYRETIN SER-6 POLYMORPHISM
AMYLOID POLYNEUROPATHY, APPALACHIAN TYPE
AMYLOIDOSIS, SYSTEMIC, NEUROPATHIC, AND LEPTOMENINGEAL
AMYLOIDOSIS, OCULOLEPTOMENINGEAL
PREALBUMIN CHICAGO
CARPAL TUNNEL SYNDROME, FAMILIAL
AMYLOID POLYNEUROPATHY, MAHLOUDJI OR MARYLAND TYPE
AMYLOIDOSIS, SENILE
AMYLOID POLYNEUROPATHY, ANDRADE OR PORTUGUESE TYPE
AMYLOIDOSIS, FAMILIAL
AMYLOID POLYNEUROPATHY, GERMAN-AMERICAN TYPE
AMYLOID POLYNEUROPATHY, RUKAVINA OR INDIANA TYPE