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Strain Detail


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 Strain information
  CARD ID
222 
Type of strain Targeted mutant. 
Strain name C57BL/6-Cdkn1btm1 
Internal Code p27KO
p27 knockout 
Submitter Unknown Unknown 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Nippon Roche Research Center 
Organization code Unknown 
Developer Keiko Nakayama 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Cdkn1b 
Gene name Cyclin-dependent kinase inhibitor 1B (P27) 
Allele symbol Cdkn1btm1 
Allele name Cdkn1b, targeted mutation 1 
MGI MGI:104565 
Chromosome 6  
Gene classification Targeted or trapped gene(knockout etc.) 
Method  
GO
GO ID GO Term GO Evidence Code
GO:0051271 negative regulation of cellular component movement IDA
GO:0031116 positive regulation of microtubule polymerization IGI
GO:0050680 negative regulation of epithelial cell proliferation IMP
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IMP
GO:0043066 negative regulation of apoptosis IMP
GO:0048839 inner ear development IMP
GO:0004860 protein kinase inhibitor activity IEA
GO:0007049 cell cycle IEA
GO:0007605 sensory perception of sound IMP
GO:0005829 cytosol IDA
more... (Total Hit Count: 20)
OMIM OMIM ID: 600778
Human Gene Symbol: CDKN1B

GO
GO ID GO Term GO Evidence Code
GO:0051271 negative regulation of cellular component movement IDA
GO:0031116 positive regulation of microtubule polymerization IGI
GO:0050680 negative regulation of epithelial cell proliferation IMP
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IMP
GO:0043066 negative regulation of apoptosis IMP
GO:0048839 inner ear development IMP
GO:0004860 protein kinase inhibitor activity IEA
GO:0007049 cell cycle IEA
GO:0007605 sensory perception of sound IMP
GO:0005829 cytosol IDA
more... (Total Hit Count: 20)
 

 Reference information
 reference information 1
  Author
Keiko Nakayama, Noriko Ishida, Michiko Shirane, Akira Inomata, Tomoaki Inoue, Nobuyuki Shishido, Ikuo Horii, Dennis Y. Loh, and Kei-ichi Nakayama 
Title Mice Lacking p27Kip1 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors 
Journal Cell 
Volume 85 
Page 707-720 
Year 1996 
PMID 8646779  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Neurobiology, cancer, Development 
  OMIM OMIM ID: 600778
Human Gene Symbol: CDKN1B
Allelic Variant Name :
MULTIPLE ENDOCRINE NEOPLASIA, TYPE IV