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Strain Detail


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 Strain information
  CARD ID
220 
Type of strain Targeted mutant. 
Strain name C57BL/6JJcl-Irf1tm1 
Internal Code
C57BL/6JJcl-IRF-1(+/-) 
Submitter Unknown Unknown 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization  
Organization code  
Developer  
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Irf1 
Gene name Interferon regulatory factor 1 
Allele symbol Irf1tm1 
Allele name Irf1, targeted mutation 1 
MGI MGI:96590 
Chromosome 11  
Gene classification Targeted or trapped gene(knockout etc.) 
Method  
GO
GO ID GO Term GO Evidence Code
GO:0043565 sequence-specific DNA binding IDA
GO:0043374 CD8-positive, alpha-beta T cell differentiation IMP
GO:0010468 regulation of gene expression IMP
GO:0005634 nucleus IC
GO:0003700 transcription factor activity IDA
GO:0003677 DNA binding IDA
GO:0006350 transcription IEA
GO:0045449 regulation of transcription IEA
GO:0006355 regulation of transcription, DNA-dependent IEA
GO:0045084 positive regulation of interleukin-12 biosynthetic process IDA, IMP
more... (Total Hit Count: 13)
OMIM OMIM ID: 147575
Human Gene Symbol: IRF1

GO
GO ID GO Term GO Evidence Code
GO:0043565 sequence-specific DNA binding IDA
GO:0043374 CD8-positive, alpha-beta T cell differentiation IMP
GO:0010468 regulation of gene expression IMP
GO:0005634 nucleus IC
GO:0003700 transcription factor activity IDA
GO:0003677 DNA binding IDA
GO:0006350 transcription IEA
GO:0045449 regulation of transcription IEA
GO:0006355 regulation of transcription, DNA-dependent IEA
GO:0045084 positive regulation of interleukin-12 biosynthetic process IDA, IMP
more... (Total Hit Count: 13)
 

 Reference information
 reference information 1
  Author
Toshifumi Matsuyama, Tohru Kimura, Motoo Kitagawa, Klaus Pfeffer, Takatoshi Kawakami, Nobumasa Watanabe, Thomas M. Kundig, Ryuichi Amakawa, Kenji Kishihara, Andrew Wakeham, Julia Potter, Caren L. Furlonger, Arumugavadivel Narendran, Haruhiko Suzuki, Pamela S. Ohashi, Christopher J. Paige, Tadatsugu Taniguchi, and Tak W. Mak 
Title Targeted Disruption of IRF-1 or IRF-2 Results in Abnormal Type I IFN Gene Induction and Aberrant Lymphocyte Development 
Journal Cell 
Volume 75 
Page 83-97 
Year 1993 
PMID 8402903  
 
 Disease , Applicable field information
  OMIM OMIM ID: 147575
Human Gene Symbol: IRF1
Allelic Variant Name :
NONSMALL CELL LUNG CANCER
GASTRIC CANCER, SOMATIC