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Strain Detail


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 Strain information
  CARD ID
2102 
Type of strain Targeted mutant. 
Strain name STOCK-Dedd1tm1Timy 
Internal Code DEDD+/- Balb/c 
Submitter Miyazaki Toru 
Submitter affiliation or code Lab of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine (CDBIM), The University of Tokyo 
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization The University of Tokyo 
Organization code  
Developer Toru Miyazaki 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Dedd 
Gene name death effector domain-containing 
Allele symbol Dedd1tm1Timy 
Allele name death effector domain-containing, Targeted mutation 1, Toru Miyazaki 
MGI MGI:1333874 
Chromosome 1 (1H2 , 79.34) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
OMIM
 
 Primer 1
  PCR Primer D5-1  ATG GCG GGC CTA AAG AGG CGG GCA 
D3-1  CTC GTC TCT TCT TGA GAG TAA CGT 
 
 Primer 2
  PCR Primer TM-1  CAG CCA GAT TTA CAT AGT GAA ATC 
NY-5  CCG CTA TCA GGA CAT AGC GTT GGC 
 

 Reference information
 reference information 1
  Author
Arai S, Miyake K, Voit R, Nemoto S, Wakeland EK, Grummt I, Miyazaki T 
Title Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1. 
Journal Proc Natl Acad Sci U S A. 
Volume 104 
Page 2289-94 
Year 2007 
PMID  
 
 reference information 2
  Author
Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T. 
Title The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation. 
Journal J Biol Chem 
Volume 284 
Page 5050-5 
Year 2009 
PMID  
 
 reference information 3
  Author
Kurabe N, Mori M, Kurokawa J, Taniguchi K, Aoyama H, Atsuda K, Nishijima A, Odawara N, Harada S, Nakashima K, Arai S, Miyazaki T 
Title The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability. 
Journal Biochem Biophys Res Commun 
Volume 39 
Page 1708-13 
Year 2009 
PMID  
 
 reference information 4
  Author
Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S, Miyazaki T 
Title Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. 
Journal J Clin Invest 
Volume 121 
Page 318-27 
Year 2011 
PMID  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Reproduction, cancer, Cell biology, Molecular biology