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Strain Detail


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 Strain information
  CARD ID
2091 
Type of strain Targeted mutant. 
Strain name B6;129-Rab8atm1Rab8btm1 
Internal Code Rab8ab DKO 
Submitter - - 
Submitter affiliation or code
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization  
Organization code  
Developer  
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks Rab8a+/-; Rab8b-/- 
 
 Gene information
 Gene information 1
  Gene symbol
Rab8b 
Gene name Rab8b, member RAS oncogene 
Allele symbol Rab8btm1 
Allele name Rab8b, member RAS oncogene, targeted mutation 1 
MGI MGI:2442982 
Chromosome 9 (36.17) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
OMIM
 
 Gene information 2
  Gene symbol
Rab8a 
Gene name Rab8a, member RAS oncogene 
Allele symbol Rab8atm1 
Allele name Rab8a, member RAS oncogene, targeted mutation 1 
MGI MGI:96960 
Chromosome 8 (34.84) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
OMIM
 
 Primer 1
  PCR Primer 8a genotype E  tgg ctt atg gca tat ctg ctg g 
8a genotype A  aag cag gcc tca act cac tga gat c 
 
 Primer 2
  PCR Primer 8a genotype E  tgg ctt atg gca tat ctg ctg g 
8a genotype R  gcc aag ttt ggg gca tag tta c 
 
 Primer 3
  PCR Primer 8bWT-S  gtt gga cat ctc ttc acc tat gc 
8bNull-AS  cag agc ctg aga agg tgc aat g 
 

 Reference information
 reference information 1
  Author
Sato T, Mushiake S, Kato Y, Sato K, Sato M, Takeda N, Ozono K, Miki K, Kubo Y, Tsuji A, Harada R, Harada A. 
Title The Rab8 GTPase regulates apical protein localization in intestinal cells. 
Journal Nature 
Volume 448 
Page 366-369 
Year 2007 
PMID  
 
 reference information 2
  Author
Takashi Sato, Tomohiko Iwano, Masataka Kunii, Shinji Matsuda, Rumiko Mizuguchi, Yongwook Jung, Haruo Hagiwara, Yoshihiro Yoshihara, Michisuke Yuzaki, Reiko Harada and Akihiro Harada 
Title Rab8a and Rab8b are essential for multiple apical transport pathways but insufficient for ciliogenesis 
Journal Journal of Cell Science 
Volume  
Page  
Year in press 
PMID  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Digestive Disorders, Metabolism, Neurobiology, Cell biology, Anatomy, Physiology