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Strain Detail


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 Strain information
  CARD ID
139 
Type of strain Targeted mutant.
Transgenic. 
Strain name STOCK-Rag2tm1WumTg(Tcra)Wum 
Internal Code (B6 x BALB/c x 129)Rag2tm1-TgN(TCR alpha) 
Submitter Shigeo Koyasu 
Submitter affiliation or code RIKEN 
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method From other organizations.
 
Origin
(In-house)
Organization Wum : Washington Univ Sch Med 
Organization code Wum 
Developer K. M. Murphy 
Origin
(From other organizations)
Organization Harvard Medical School 
Organization code Wum 
Developer  
Year introduced 1994  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Tcra 
Gene name T-cell receptor alpha chain 
Allele symbol  
Allele name  
MGI MGI:98553 
Chromosome  
Gene classification Gene to express(transgenic) 
Method Other 
GO
GO ID GO Term GO Evidence Code
GO:0009897 external side of plasma membrane IDA
GO:0002360 T cell lineage commitment IMP
GO:0009986 cell surface IDA
GO:0042105 alpha-beta T cell receptor complex IDA
OMIM
GO
GO ID GO Term GO Evidence Code
GO:0009897 external side of plasma membrane IDA
GO:0002360 T cell lineage commitment IMP
GO:0009986 cell surface IDA
GO:0042105 alpha-beta T cell receptor complex IDA
 
 Gene information 2
  Gene symbol
Rag2 
Gene name Recombination-activating gene 2 
Allele symbol  
Allele name  
MGI MGI:98553 
Chromosome 2 (56.0cM) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Other 
GO
GO ID GO Term GO Evidence Code
GO:0009897 external side of plasma membrane IDA
GO:0002360 T cell lineage commitment IMP
GO:0009986 cell surface IDA
GO:0042105 alpha-beta T cell receptor complex IDA
OMIM
GO
GO ID GO Term GO Evidence Code
GO:0009897 external side of plasma membrane IDA
GO:0002360 T cell lineage commitment IMP
GO:0009986 cell surface IDA
GO:0042105 alpha-beta T cell receptor complex IDA
 

 Reference information
 reference information 1
  Author
Shigeo Koyasu, Linda K. Clayton, Adam Lerner, Hans Heiken, Alysia Parkes and Ellis L. Reinherz 
Title Pre-TCR signaling components trigger transcriptional activation of a rearranged TCRα gene locus and silencing of the pre-TCRα locus: implications for intrathymic differentiation 
Journal International Immunology 
Volume
Page 1475-1480 
Year 1997 
PMID 9352352