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Strain Detail


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 Strain information
  CARD ID
92 
Type of strain Targeted mutant. 
Strain name C57BL/6-Rag1tm2(GFP)Imku 
Internal Code
RAG 1 knockin mice 86 
Submitter Nobuo SAKAGUCHI 
Submitter affiliation or code Kumamoto University School of Medicine, Department of Immunoloy 
Stock Type  
Material Transfer Conditions Other conditions. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Imku 
Organization code Imku 
Developer Nobuo Sakaguchi 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Rag1 
Gene name Recombination-activating gene 1 
Allele symbol  
Allele name  
MGI MGI:97848 
Chromosome 2 (56.0cM) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Other 
OMIM OMIM ID: 179615
Human Gene Symbol: RAG1

 
 Gene information 2
  Gene symbol
GFP 
Gene name Green Fluorescence Protein 
Allele symbol  
Allele name  
MGI  
Chromosome  
Gene classification Targeted or trapped gene(knockout etc.) 
Method Other 
OMIM
 

 Reference information
 reference information 1
  Author
Naomi Kuwata, Hideya Igarashi, Takafumi Ohmura, Shinichi Aizawa, and Nobuo Sakaguchi 
Title Cutting Edge: Absence of Expression of RAG1 in Peritoneal B-1 Cells Detected by Knocking into RAG1 Locus with Green Fluorescent Protein Gene 
Journal The Journal of Immunology 
Volume 163 
Page 6355-6359 
Year 1999 
PMID 10586023  
 
 Disease , Applicable field information
  OMIM OMIM ID: 179615
Human Gene Symbol: RAG1
Allelic Variant Name :
RECOMBINATION ACTIVATING GENE 1 POLYMORPHISM
COMBINED CELLULAR AND HUMORAL IMMUNE DEFECTS WITH GRANULOMAS
ALPHA/BETA T-CELL LYMPHOPENIA WITH GAMMA/DELTA T-CELL EXPANSION, SEVERE
OMENN SYNDROME
SEVERE COMBINED IMMUNODEFICIENCY, B CELL-NEGATIVE