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Strain Detail


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 Strain information
  CARD ID
88 
Type of strain Targeted mutant. 
Strain name C57BL/6-Rag1tm1(GFP)Imku 
Internal Code
RAG 1 knock-in mouse 
Submitter Nobuo SAKAGUCHI 
Submitter affiliation or code Kumamoto University School of Medicine, Department of Immunoloy 
Stock Type  
Material Transfer Conditions Other conditions. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Imku 
Organization code Imku 
Developer Nobuo Sakaguchi 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
GFP 
Gene name Green Fluorescence Protein 
Allele symbol  
Allele name  
MGI  
Chromosome  
Gene classification Targeted or trapped gene(knockout etc.) 
Method Other 
OMIM
 
 Gene information 2
  Gene symbol
Rag1 
Gene name Recombination-activating gene 1 
Allele symbol  
Allele name  
MGI MGI:97848 
Chromosome 2 (56.0cM) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Other 
OMIM OMIM ID: 179615
Human Gene Symbol: RAG1

 

 Reference information
 reference information 1
  Author
Robert C. Rickert, Jurgen Roes and Klaus Rajewsky 
Title B Iymphocyte-specific, Cre-mediated mutagenesis in mice 
Journal Nucleic Acids Research 
Volume 25 
Page 1317-1318 
Year 1997 
PMID 9092650  
 
 reference information 2
  Author
Yousuke Takahama, Kazuhito Ohishi, Yayoi Tokoro, Takehiko Sugawara, Yasuhide Yoshimura, Masaru Okabe, Taroh Kinoshita and Junji Takeda 
Title Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene 
Journal Eur. J. Immunol. 
Volume 28 
Page 2159-2166 
Year 1998 
PMID 9692885  
 
 reference information 3
  Author
Naomi Kuwata, Hideya Igarashi, Takafumi Ohmura, Shinichi Aizawa, and Nobuo Sakaguchi 
Title Cutting Edge: Absence of Expression of RAG1 in Peritoneal B-1 Cells Detected by Knocking into RAG1 Locus with Green Fluorescent Protein Gene 
Journal The Journal of Immunology 
Volume 163 
Page 6355-6359 
Year 1999 
PMID 10586023  
 
 reference information 4
  Author
Araki, K., Araki, M., Miyazaki, J. & Vassalli, P. 
Title Site-Specific Recombination of a Transgene in Fertilized Eggs by Transient Expression of Cre Recombinase 
Journal Proc. Natl. Acad. Sci. USA 
Volume 92 
Page 160-164 
Year 1995 
PMID 7816809  
 
 Disease , Applicable field information
  OMIM OMIM ID: 179615
Human Gene Symbol: RAG1
Allelic Variant Name :
SEVERE COMBINED IMMUNODEFICIENCY, B CELL-NEGATIVE
COMBINED CELLULAR AND HUMORAL IMMUNE DEFECTS WITH GRANULOMAS
OMENN SYNDROME
ALPHA/BETA T-CELL LYMPHOPENIA WITH GAMMA/DELTA T-CELL EXPANSION, SEVERE
RECOMBINATION ACTIVATING GENE 1 POLYMORPHISM