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Strain Detail


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 Strain information
  CARD ID
2062 
Type of strain Targeted mutant. 
Strain name B6;129-Rab8atm1 Rab8btm1 
Internal Code rab8a,rab8b double knockout mouse 
Submitter - - 
Submitter affiliation or code
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization I.M.C.R., Gunma Univ, 
Organization code  
Developer Akihiro Harada 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Rab8a 
Gene name RAB8A, member RAS oncogene family 
Allele symbol Rab8atm1 
Allele name RAB8A, member RAS oncogene family, targeted mutation 1 
MGI MGI:96960 
Chromosome 8 (34.84) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
OMIM
 
 Gene information 2
  Gene symbol
Rab8b 
Gene name RAB8B, member RAS oncogene family 
Allele symbol Rab8btm1 
Allele name RAB8B, member RAS oncogene family, targeted mutation 1 
MGI MGI:2442982 
Chromosome 9 (36.17) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
OMIM
 
 Primer 1
  PCR Primer 8bWT-S  GTT GGA CAT CTC TTC ACC TAT GC 
8bWT-AS  CAG AAG CCC TTC CTC GTT CCT GG 
 

 Reference information
 reference information 1
  Author
Sato T, Mushiake S, Kato Y, Sato K, Sato M, Takeda N, Ozono K, Miki K, Kubo Y, Tsuji A, Harada R, Harada A. 
Title The Rab8 GTPase regulates apical protein localization in intestinal cells. 
Journal Nature 
Volume 448 
Page 366-369 
Year 2007 
PMID  
 
 reference information 2
  Author
Takashi Sato, Tomohiko Iwano, Masataka Kunii, Shinji Matsuda, Rumiko Mizuguchi, Yongwook Jung, Haruo Hagiwara, Yoshihiro Yoshihara, Michisuke Yuzaki, Reiko Harada and Akihiro Harada 
Title Rab8a and Rab8b are essential for multiple apical transport pathways but insufficient for ciliogenesis 
Journal Journal of Cell Science 
Volume  
Page  
Year in press 
PMID  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Metabolism, Neurobiology, Cell biology, Anatomy, Physiology