| |
CARD ID
 |
586 |
| Type of strain |
Targeted mutant. |
| Strain name |
B6;129S4-Pargtm1Ncc/Csk |
| Internal Code |
B6;129S4-Pargtm1Ncc/Csk |
| Submitter |
Unknown Unknown |
| Submitter affiliation or code |
|
| Stock Type |
|
| Material Transfer Conditions |
It is necessary to consent to the submitter.
|
| Production method |
In-house breading.
|
Origin
(In-house) |
Organization |
Chugai Research Institute for Medical Science Inc., National Cancer Center Research Institute |
| Organization code |
Csk, Ncc |
| Developer |
Kou-ichi Jishage, Mitsuko Masutani |
Origin
(From other organizations) |
Organization |
|
| Organization code |
|
| Developer |
|
| Year introduced |
|
Introduced
Generation |
|
| Remarks |
|
| |
Gene symbol
|
Parg |
| Gene name |
Poly (ADP-ribose) glycohydrolase |
| Allele symbol |
Pargtm1Ncc |
| Allele name |
Parg,National Cancer Center Research Institute |
| MGI |
MGI:1347094 |
| Chromosome |
14 |
| Gene classification |
Targeted or trapped gene(knockout etc.) |
| Method |
Electroporation |
| OMIM |
OMIM ID:
603501
Human Gene Symbol:
PARG
|
|
| |
PCR Primer |
mpG2061S
|
5' ctc ggc cgt ggc cgc gac aag c 3'
|
|
mpG2318A
|
5' cct ccg ctc ggc agc agg ga 3'
|
|
| reference information 1 |
| |
Author
|
Atsushi Shibata, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani |
| Title |
Parp-1 deficiency causes an increase of deletion mutations and insertions/ rearrangements in vivo after treatment with an alkylating agent |
| Journal |
Oncogene |
| Volume |
24 |
| Page |
1328-1337 |
| Year |
2005 |
|
PMID
|
15608683
|
|
| reference information 2 |
| |
Author
|
MITSUKO MASUTANI, HIROSHI SUZUKI, NOBUO KAMADA, MIHO WATANABE, OTOYA UEDA, TADASHIGE NOZAKI, KOU-ICHI JISHAGE, TAKESHI WATANABE, TETSURO SUGIMOTO, HITOSHI NAKAGAMA, TAKAHIRO OCHIYA, AND TAKASHI SUGIMURA |
| Title |
Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes |
| Journal |
Proc. Natl. Acad. Sci. USA |
| Volume |
96 |
| Page |
2301-2304 |
| Year |
1999 |
|
PMID
|
10051636
|
|
| reference information 3 |
| |
Author
|
T. Nohmi, M. Katoh, H. Suzuki, M. Matsui, M. Yamada, M. Watanabe, M. Suzuki, N. Horiya, O. Ueda, T. Shibuya, H. Ikeda, and T. Sofuni |
| Title |
A NewTransgenic Mouse Mutagenesis Test System Using Spi- and 6-Thioguanine Selections |
| Journal |
Environmental and Molecular Mutagenesis |
| Volume |
28 |
| Page |
465-470 |
| Year |
1996 |
|
PMID
|
8991079
|
|
|
Disease , Applicable field information
|
| |
Disease name,
Applicable field
|
Metabolism, Immunology
|
| |
OMIM |
OMIM ID:
603501
Human Gene Symbol:
PARG
|
|
|
