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CARD

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Strain Detail

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Strain information

	CARD ID		292
	Type of strain		Spontaneous/Chemical induced mutant.
	Strain name		C3101F₁-Pax6^Sey-3H
	Internal Code
	Submitter		Nitta Yumiko
	Submitter affiliation or code		Ros.Inst. Radiat.Biot.Med., Hiroshima University
	Stock Type
	Material Transfer Conditions		No condition.
	Production method		From other organizations.
	Origin (In-house)	Organization
		Organization code
		Developer
	Origin (From other organizations)	Organization	MRC
		Organization code
		Developer	B. M. Cattanach
		Year introduced	October 2000
		Introduced Generation	F2
	Remarks

Gene information

Gene information 1

Gene symbol

Pax6

Gene name

paired box gene 6

Allele symbol

Allele name

MGI

Chromosome

2 (58.0cM)

Gene classification

Other gene(mutant etc.)

Method

GO

GO ID	GO Term	GO Evidence Code
GO:0005634	nucleus	IDA
GO:0006350	transcription	IEA
GO:0005667	transcription factor complex	TAS
GO:0003700	transcription factor activity	TAS, IDA
GO:0003677	DNA binding	IDA
GO:0007275	multicellular organismal development	IEA
GO:0030154	cell differentiation	IMP
GO:0007411	axon guidance	IMP
GO:0030334	regulation of cell migration	IMP
GO:0008285	negative regulation of cell proliferation	IMP
more... (Total Hit Count: 57)

OMIM

OMIM ID: 607108
Human Gene Symbol: PAX6

GO

GO ID	GO Term	GO Evidence Code
GO:0005634	nucleus	IDA
GO:0006350	transcription	IEA
GO:0005667	transcription factor complex	TAS
GO:0003700	transcription factor activity	TAS, IDA
GO:0003677	DNA binding	IDA
GO:0007275	multicellular organismal development	IEA
GO:0030154	cell differentiation	IMP
GO:0007411	axon guidance	IMP
GO:0030334	regulation of cell migration	IMP
GO:0008285	negative regulation of cell proliferation	IMP
more... (Total Hit Count: 57)

Reference information

reference information 1

	Author	Yumiko Nitta, Kazuko Yoshida, Kimio Tanaka, Jo Peters and Bruce M. Cattanach
	Title	The Mouse Small Eye Mutant, Del(2)Sey3H, Which Deletes the Putative Tumor Suppressor Region of the Radiation-induced Acute Myeloid Leukemia is Susceptible to Radiation.
	Journal
	Volume
	Page
	Year
	PMID

Disease , Applicable field information

Disease name,
Applicable field

cancer, Development

OMIM

OMIM ID: 607108
Human Gene Symbol: PAX6
Allelic Variant Name :

•	FOVEAL HYPOPLASIA WITH ANTERIOR SEGMENT ANOMALIES
•	FOVEAL HYPOPLASIA AND PRESENILE CATARACT SYNDROME
•	PETERS ANOMALY
•	KERATITIS, AUTOSOMAL DOMINANT
•	ANIRIDIA
•	ECTOPIA PUPILLAE
•	OPTIC NERVE HYPOPLASIA, BILATERAL
•	COLOBOMA OF OPTIC NERVE
•	OPTIC NERVE APLASIA, BILATERAL
•	FOVEAL HYPOPLASIA, ISOLATED
•	ANIRIDIA, CEREBELLAR ATAXIA, AND MENTAL DEFICIENCY
•	MORNING GLORY DISC ANOMALY
•	CATARACTS, CONGENITAL, WITH LATE-ONSET CORNEAL DYSTROPHY