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Strain Detail

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Strain information

	CARD ID		131
	Type of strain		Targeted mutant.
	Strain name		Agt^tm2Smi
	Internal Code		ANG2/2
	Submitter		Unknown Unknown
	Submitter affiliation or code
	Stock Type
	Material Transfer Conditions		No condition.
	Production method		From other organizations.
	Origin (In-house)	Organization
		Organization code
		Developer
	Origin (From other organizations)	Organization	Oliver Smithie's Labo, University of North Carolina
		Organization code	Smi
		Developer
		Year introduced	1997
		Introduced Generation
	Remarks

Gene information

Gene information 1

Gene symbol

Agt

Gene name

Angiotensinogen

Allele symbol

Allele name

MGI

Chromosome

Gene classification

Targeted or trapped gene(knockout etc.)

Method

GO

GO ID	GO Term	GO Evidence Code
GO:0009651	response to salt stress	IMP
GO:0008217	regulation of blood pressure	IMP
GO:0005576	extracellular region	IEA
GO:0004867	serine-type endopeptidase inhibitor activity	IEA
GO:0005615	extracellular space	IDA
GO:0030198	extracellular matrix organization	IMP
GO:0030432	peristalsis	IMP
GO:0007160	cell-matrix adhesion	IMP
GO:0009409	response to cold	IMP
GO:0008285	negative regulation of cell proliferation	IMP
more... (Total Hit Count: 40)

OMIM

OMIM ID: 106150
Human Gene Symbol: AGT

GO

GO ID	GO Term	GO Evidence Code
GO:0009651	response to salt stress	IMP
GO:0008217	regulation of blood pressure	IMP
GO:0005576	extracellular region	IEA
GO:0004867	serine-type endopeptidase inhibitor activity	IEA
GO:0005615	extracellular space	IDA
GO:0030198	extracellular matrix organization	IMP
GO:0030432	peristalsis	IMP
GO:0007160	cell-matrix adhesion	IMP
GO:0009409	response to cold	IMP
GO:0008285	negative regulation of cell proliferation	IMP
more... (Total Hit Count: 40)

Reference information

reference information 1

	Author	HYUNG-SUK KIM, JOHN H. KREGE, KIMBERLY D. KLUCKMAN, JOHN R. HAGAMAN, JEFFREY B. HODGIN, CHRISTOPHER F. BEST, J. CHARLES JENNETTE, THOMAS M. COFFMAN, NOBUYO MAEDA, AND OLIVER SMITHIES
	Title	Genetic control of blood pressure and the angiotensinogen locus
	Journal	Proc. Natl. Acad. Sci. USA
	Volume	92
	Page	2735-2739
	Year	1995
	PMID	7708716

Disease , Applicable field information

OMIM

OMIM ID: 106150
Human Gene Symbol: AGT
Allelic Variant Name :

•	RENAL TUBULAR DYSGENESIS
•	HYPERTENSION, ESSENTIAL, SUSCEPTIBILITY TO