| |
CARD ID
 |
540 |
| Type of strain |
Targeted mutant. |
| Strain name |
B6.129-Chrm3tm1 |
| Internal Code |
3NJ
B6.129-Chrm3tm1 |
| Submitter |
Unknown Unknown |
| Submitter affiliation or code |
|
| Stock Type |
|
| Material Transfer Conditions |
Other conditions.
|
| Production method |
In-house breading.
|
Origin
(In-house) |
Organization |
Graduate Sch. Pharm. Sci., Univ. Tokyo |
| Organization code |
|
| Developer |
MATSUI Minoru |
Origin
(From other organizations) |
Organization |
|
| Organization code |
|
| Developer |
|
| Year introduced |
|
Introduced
Generation |
|
| Remarks |
|
| |
Gene symbol
|
Chrm3 |
| Gene name |
cholinergic receptor, muscarinic 3, cardia |
| Allele symbol |
Chrm3tm1 |
| Allele name |
targeted mutation 1 |
| MGI |
MGI:88398 |
| Chromosome |
13 (7.0 cM) |
| Gene classification |
Targeted or trapped gene(knockout etc.) |
| Method |
Electroporation |
| OMIM |
OMIM ID:
118494
Human Gene Symbol:
CHRM3
|
|
| reference information 1 |
| |
Author
|
Hiroshi Karasawa, Makoto M. Taketo, Minoru Matsui |
| Title |
Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4 |
| Journal |
European Journal of Pharmacology |
| Volume |
468 |
| Page |
15-19 |
| Year |
2003 |
|
PMID
|
12729838
|
|
| reference information 2 |
| |
Author
|
Minoru Matsui, Daisuke Motomura, Hiroshi Karasawa, Toru Fujikawa, Jian Jiang, Yuriko Komiya, Shin-ichi Takahashi, and Makoto M. Taketo |
| Title |
Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype |
| Journal |
PNAS |
| Volume |
97 |
| Page |
9579-9584 |
| Year |
2000 |
|
PMID
|
10944224
|
|
| reference information 3 |
| |
Author
|
Minoru Matsui, Daisuke Motomura, Toru Fujikawa, Jian Jiang, Shin-ichi Takahashi, Toshiya Manabe, and Makoto M. Taketo |
| Title |
Mice Lacking M2 and M3 Muscarinic Acetylcholine Receptors Are Devoid of Cholinergic Smooth Muscle Contractions But Still Viable |
| Journal |
The Journal of Neuroscience |
| Volume |
22 |
| Page |
10627-10632 |
| Year |
2002 |
|
PMID
|
12486155
|
|
| reference information 4 |
| |
Author
|
Takako Ohno-Shosaku, Minoru Matsui, Yuko Fukudome, Jumpei Shosaku, Hiroshi Tsubokawa, Makoto M. Taketo, Toshiya Manabe and Masanobu Kano |
| Title |
Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus |
| Journal |
European Journal of Neuroscience |
| Volume |
18 |
| Page |
109-116 |
| Year |
2003 |
|
PMID
|
12859343
|
|
| reference information 5 |
| |
Author
|
Takeshi Nakamura, Minoru Matsui, Keiko Uchida, Akira Futatsugi, Shinji Kusakawa, Nagisa Matsumoto, Kyoko Nakamura, Toshiya Manabe, Makoto M. Taketo and Katsuhiko Mikoshiba |
| Title |
M3 muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice |
| Journal |
J Physiol |
| Volume |
558 |
| Page |
561-575 |
| Year |
2004 |
|
PMID
|
15146045
|
|
|
Disease , Applicable field information
|
| |
Disease name,
Applicable field
|
Metabolism, Neurobiology, Dermatology, cancer, Immunology, Development, Anatomy, Physiology
|
| |
OMIM |
OMIM ID:
118494
Human Gene Symbol:
CHRM3
|
|
|
