| |
CARD ID
 |
1093 |
| Type of strain |
Targeted mutant. |
| Strain name |
B6.129-Edg3tm1Jch |
| Internal Code |
SIP3-Knockout |
| Submitter |
ISHII ISAO |
| Submitter affiliation or code |
Showa Pharmaceutical University |
| Stock Type |
|
| Material Transfer Conditions |
It is necessary to consent to the submitter.
|
| Production method |
From other organizations.
|
Origin
(In-house) |
Organization |
Showa Pharmaceutical University |
| Organization code |
|
| Developer |
Isao Ishii |
Origin
(From other organizations) |
Organization |
The Scripps Research Institute |
| Organization code |
Jch |
| Developer |
Dr. Jerold Chun |
| Year introduced |
April
2005
|
Introduced
Generation |
N5+F? |
| Remarks |
|
| |
Gene symbol
|
Edg3 |
| Gene name |
endothelial differentiation, sphingolipid G-protein-coupled receptor,3 |
| Allele symbol |
Edg3tm1Jch |
| Allele name |
targeted mutation 1, Jerold Chun |
| MGI |
|
| Chromosome |
13 (13B1 ) |
| Gene classification |
Targeted or trapped gene(knockout etc.) |
| Method |
MicroInjection |
| OMIM |
|
|
| |
PCR Primer |
Edg3-1(HX1)
|
ATCGATACCGTCGTCGACCT
|
|
Edg3-2(B3-back)
|
CACAGCAAGCAGACCTCCAGA
|
|
| reference information 1 |
| |
Author
|
Isao Ishii, Beth Friedman, Xiaoqin Ye, Shuji Kawamura, Christine McGiffert, James J. A. Contos, Marcy A. Kingsbury, Guangfa Zhang, Joan Heller Brown, and Jerold Chun |
| Title |
Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor,LPB3/EDG-3 |
| Journal |
J. Biol. Chem. |
| Volume |
276 |
| Page |
33697-33704 |
| Year |
2001 |
|
PMID
|
|
|
| reference information 2 |
| |
Author
|
Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, et al. |
| Title |
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. |
| Journal |
Cardiovasc Res |
| Volume |
85 |
| Page |
484-493 |
| Year |
2010 |
|
PMID
|
|
|
| reference information 3 |
| |
Author
|
Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, et al. |
| Title |
Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. |
| Journal |
Am J Physiol Heart Circ Physiol |
| Volume |
292 |
| Page |
H2944-H2951 |
| Year |
2007 |
|
PMID
|
|
|
|
Disease , Applicable field information
|
| |
Disease name,
Applicable field
|
Metabolism, Neurobiology, Immunology, Development, Physiology
|
|
|
