| |
CARD ID
 |
1073 |
| Type of strain |
Targeted mutant. |
| Strain name |
B6.129-S1pr2tm1Jch |
| Internal Code |
SIP2-Knockout |
| Submitter |
ISHII ISAO |
| Submitter affiliation or code |
Showa Pharmaceutical University |
| Stock Type |
|
| Material Transfer Conditions |
It is necessary to consent to the submitter.
|
| Production method |
From other organizations.
|
Origin
(In-house) |
Organization |
Showa Pharmaceutical University |
| Organization code |
|
| Developer |
Isao Ishii |
Origin
(From other organizations) |
Organization |
The Scripps Research Institute |
| Organization code |
Jch |
| Developer |
Dr. Jerold Chun |
| Year introduced |
April
2005
|
Introduced
Generation |
N5+F? |
| Remarks |
|
| |
Gene symbol
|
S1pr2 (Synonym: Edg5) |
| Gene name |
Endothelial differentiation, sphingolipid G-protein-coupled receptor,5 |
| Allele symbol |
S1pr2tm1Jch |
| Allele name |
targeted mutation 1, Jerold Chun |
| MGI |
|
| Chromosome |
9 (6.0) |
| Gene classification |
Targeted or trapped gene(knockout etc.) |
| Method |
MicroInjection |
| OMIM |
|
|
| |
PCR Primer |
Edg5-1(B2-neo)
|
GCTAAAGCGCATGCTCCAGACT
|
|
Edg5-2(B2-SA)
|
ACACCCTTTGTATCAAGTGGCAA
|
|
| reference information 1 |
| |
Author
|
Isao Ishii, Xiaoqin Ye, Beth Friedman, Shuji Kawamura, James J. A. Contos, Marcy A. Kingsbury, Amy H. Yang, Guangfa Zhang, Joan Heller Brown, and Jerold Chun |
| Title |
Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3 |
| Journal |
J. Biol. Chem. |
| Volume |
277 |
| Page |
25152-25159 |
| Year |
2002 |
|
PMID
|
|
|
| reference information 2 |
| |
Author
|
Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, et al. |
| Title |
Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice. |
| Journal |
Endocrinology |
| Volume |
157 |
| Page |
1839-1851 |
| Year |
2016 |
|
PMID
|
|
|
| reference information 3 |
| |
Author
|
Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, et al. |
| Title |
Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2. |
| Journal |
Epilepsy Behav |
| Volume |
22 |
| Page |
659-665 |
| Year |
2011 |
|
PMID
|
|
|
| reference information 4 |
| |
Author
|
Imasawa T, Koike K, Ishii I, Chun J, Yatomi Y. |
| Title |
Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells. |
| Journal |
Biochem Biophys Res Commun |
| Volume |
392 |
| Page |
207-211 |
| Year |
2010 |
|
PMID
|
|
|
|
Disease , Applicable field information
|
| |
Disease name,
Applicable field
|
Metabolism, Neurobiology, Dermatology, Immunology, Development, Physiology
|
|
|
