CARD R-BASE ( Mouse Strain Resource )

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CARD

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Strain Detail

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Strain information

	CARD ID		398
	Type of strain		Spontaneous/Chemical induced mutant.
	Strain name		C3101F₁-Pax6^Sey-3H
	Internal Code		C3H/HeNCrj-Pax6^Sey-3H
	Submitter		Nitta Yumiko
	Submitter affiliation or code		Ros.Inst. Radiat.Biot.Med., Hiroshima University
	Stock Type
	Material Transfer Conditions		It is necessary to consent to the submitter.
	Production method		In-house breading.
	Origin (In-house)	Organization
		Organization code
		Developer
	Origin (From other organizations)	Organization
		Organization code
		Developer
		Year introduced
		Introduced Generation
	Remarks

Gene information

Gene information 1

Gene symbol

Pax6

Gene name

paired box gene 6

Allele symbol

Allele name

MGI

Chromosome

2

Gene classification

Other gene(mutant etc.)

Method

GO

GO ID	GO Term	GO Evidence Code
GO:0005634	nucleus	IDA
GO:0006350	transcription	IEA
GO:0005667	transcription factor complex	TAS
GO:0003700	transcription factor activity	TAS, IDA
GO:0003677	DNA binding	IDA
GO:0007275	multicellular organismal development	IEA
GO:0030154	cell differentiation	IMP
GO:0007411	axon guidance	IMP
GO:0030334	regulation of cell migration	IMP
GO:0008285	negative regulation of cell proliferation	IMP
more... (Total Hit Count: 57)

OMIM

OMIM ID: 607108
Human Gene Symbol: PAX6

GO

GO ID	GO Term	GO Evidence Code
GO:0005634	nucleus	IDA
GO:0006350	transcription	IEA
GO:0005667	transcription factor complex	TAS
GO:0003700	transcription factor activity	TAS, IDA
GO:0003677	DNA binding	IDA
GO:0007275	multicellular organismal development	IEA
GO:0030154	cell differentiation	IMP
GO:0007411	axon guidance	IMP
GO:0030334	regulation of cell migration	IMP
GO:0008285	negative regulation of cell proliferation	IMP
more... (Total Hit Count: 57)

Primer 1

	PCR Primer	primerA	5'(gtg ggg gtg ata cct gag g)3'
		primerB	3'(aga cag acc tgt agt gaa att gtc a)5'

Reference information

reference information 1

	Author	Ando, Yuichi; Beck, Yoshifumi; Tomikawa, Shinji; Eriguchi, Masazumi; Muto, Tetsuichiro; Takiguchi, Masafumi
	Title	CELL-MEDIATED GRAFT REJECTION OBSERVED IN TWO LINES OF HUMAN HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN CLASS I TRANSGENIC MICE¹
	Journal	Transplantation
	Volume	68
	Page	904-908
	Year	1999
	PMID	10515394

Disease , Applicable field information

OMIM

OMIM ID: 607108
Human Gene Symbol: PAX6
Allelic Variant Name :

•	ECTOPIA PUPILLAE
•	FOVEAL HYPOPLASIA WITH ANTERIOR SEGMENT ANOMALIES
•	ANIRIDIA
•	CATARACTS, CONGENITAL, WITH LATE-ONSET CORNEAL DYSTROPHY
•	KERATITIS, AUTOSOMAL DOMINANT
•	PETERS ANOMALY
•	ANIRIDIA, CEREBELLAR ATAXIA, AND MENTAL DEFICIENCY
•	OPTIC NERVE APLASIA, BILATERAL
•	COLOBOMA OF OPTIC NERVE
•	OPTIC NERVE HYPOPLASIA, BILATERAL
•	MORNING GLORY DISC ANOMALY
•	FOVEAL HYPOPLASIA, ISOLATED
•	FOVEAL HYPOPLASIA AND PRESENILE CATARACT SYNDROME