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Strain Detail

 - Strains   - Genes   - Reference   - Disease,Applicable field 
 Strain information
  CARD ID
 387 
Type of strain Targeted mutant.
Transgenic. 
Strain name B6;129-Ednrbtm1Ywa Tg(DBH-Ednrb)Ywa 
Internal Code ENRB•Tg
B6;129-Ednrbtm1Ywa Tg(DBH-Ednrb)Ywa 
Submitter Kato Masashi 
Submitter affiliation or code Nagoya University Graduate School of Medicine Department of Occupational and Environmental Health 
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method From other organizations.
 
Origin
(In-house)		 Organization  
Organization code  
Developer  
Origin
(From other organizations)		 Organization Yanagisawa Masashi 
Organization code Ywa 
Developer The University of Texas 
Year introduced October 2003  
Introduced 
Generation		 F1 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
 Ednrb 
Gene name endothelin receptor type B 
Allele symbol  
Allele name  
MGI MGI:102720 
Chromosome  
Gene classification Gene to express(transgenic) 
Method Electroporation 
GO
GO ID GO Term GO Evidence Code
GO:0004930 G-protein coupled receptor activity IEA
GO:0004872 receptor activity IEA
GO:0007165 signal transduction IEA
GO:0004962 endothelin receptor activity IMP
GO:0001600 endothelin-B receptor activity IDA
GO:0008217 regulation of blood pressure IMP
GO:0007186 G-protein coupled receptor protein signaling pathway IDA, IGI
GO:0006885 regulation of pH IMP
GO:0007422 peripheral nervous system development IMP
more... (Total Hit Count: 21)
OMIM OMIM ID: 131244
Human Gene Symbol: EDNRB

GO
GO ID GO Term GO Evidence Code
GO:0004930 G-protein coupled receptor activity IEA
GO:0004872 receptor activity IEA
GO:0007165 signal transduction IEA
GO:0004962 endothelin receptor activity IMP
GO:0001600 endothelin-B receptor activity IDA
GO:0008217 regulation of blood pressure IMP
GO:0007186 G-protein coupled receptor protein signaling pathway IDA, IGI
GO:0006885 regulation of pH IMP
GO:0007422 peripheral nervous system development IMP
more... (Total Hit Count: 21)
 
 Gene information 2
  Gene symbol
 Ednrb 
Gene name endothelin receptor type B 
Allele symbol  
Allele name  
MGI MGI:102720 
Chromosome 14  
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
GO
GO ID GO Term GO Evidence Code
GO:0004930 G-protein coupled receptor activity IEA
GO:0004872 receptor activity IEA
GO:0007165 signal transduction IEA
GO:0004962 endothelin receptor activity IMP
GO:0001600 endothelin-B receptor activity IDA
GO:0008217 regulation of blood pressure IMP
GO:0007186 G-protein coupled receptor protein signaling pathway IDA, IGI
GO:0006885 regulation of pH IMP
GO:0007422 peripheral nervous system development IMP
more... (Total Hit Count: 21)
OMIM OMIM ID: 131244
Human Gene Symbol: EDNRB

GO
GO ID GO Term GO Evidence Code
GO:0004930 G-protein coupled receptor activity IEA
GO:0004872 receptor activity IEA
GO:0007165 signal transduction IEA
GO:0004962 endothelin receptor activity IMP
GO:0001600 endothelin-B receptor activity IDA
GO:0008217 regulation of blood pressure IMP
GO:0007186 G-protein coupled receptor protein signaling pathway IDA, IGI
GO:0006885 regulation of pH IMP
GO:0007422 peripheral nervous system development IMP
more... (Total Hit Count: 21)
 
 Primer 1
  PCR Primer primerA  5'(ctt ggg tgg aga ggc tat tc)3' 
primerB  5'(agg tga gat gac agg aga tc)3' 
 

 Reference information
 reference information 1
  Author
 Cheryl E. Gariepy, S. Clay Williams, James A. Richardson, Robert E. Hammer, and Masashi Yanagisawa 
Title Transgenic Expression of the Endothelin-B Receptor Prevents Congenital Intestinal Aganglionosis in a Rat Model of Hirschsprung Disease 
Journal J. Clin. Invest. 
Volume 102 
Page 1092-1101 
Year 1998 
PMID 9739043  
 
 reference information 2
  Author
 Kiminori Hosoda, Robert E. Hammer, James A. Richardson, Amy Greenstein Baynash, Jason C. Cheung, Adel Giaid, and Masashi Yanagisawa 
Title Targeted and Natural (Piebald-Lethal) Mutations of Endothelin-B Receptor Gene Produce Megacolon Associated with Spotted Coat Color in Mice 
Journal Cell 
Volume 79 
Page 1267-1276 
Year 1994 
PMID 8001159  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Dermatology, cancer 
  OMIM OMIM ID: 131244
Human Gene Symbol: EDNRB
Allelic Variant Name :
•
ABCD SYNDROME
•
WAARDENBURG-SHAH SYNDROME
•
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 2

OMIM ID: 131244
Human Gene Symbol: EDNRB
Allelic Variant Name :
•
ABCD SYNDROME
•
WAARDENBURG-SHAH SYNDROME
•
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 2

 
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