| |
CARD ID
 |
2362 |
| Type of strain |
Targeted mutant. |
| Strain name |
C3H/HeJ-Cbstm1Unc |
| Internal Code |
C3H/HeJ-Cbs-knockout |
| Submitter |
ISHII ISAO |
| Submitter affiliation or code |
Showa Pharmaceutical University |
| Stock Type |
|
| Material Transfer Conditions |
It is necessary to consent to the submitter.
|
| Production method |
In-house breading.
|
Origin
(In-house) |
Organization |
Showa Pharmaceutical University |
| Organization code |
|
| Developer |
Isao Ishii |
Origin
(From other organizations) |
Organization |
|
| Organization code |
|
| Developer |
|
| Year introduced |
|
Introduced
Generation |
|
| Remarks |
|
| |
Gene symbol
|
Cbs |
| Gene name |
cystathionine beta-synthase |
| Allele symbol |
Cbstm1Unc |
| Allele name |
cystathionine beta-synthase, targeted mutation 1 |
| MGI |
MGI:88285 |
| Chromosome |
17 (16.93) |
| Gene classification |
Targeted or trapped gene(knockout etc.) |
| Method |
MicroInjection |
| OMIM |
|
|
| |
PCR Primer |
CBS-KO-1 (Common)
|
CGGATGACCTGCATTCATCT
|
|
CBS-KO-2 (WT specific)
|
GAAGTGGAGCTATCAGAGCA
|
|
CBS-KO-3 (KO specific)
|
GAGGTCGACGGTATCGATA
|
|
| reference information 1 |
| |
Author
|
Akahoshi, N., Kobayashi, C., Ishizaki, Y., Izumi, T., Himi, T., Suematsu, M., Ishii, I. |
| Title |
Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. |
| Journal |
Hum Mol Genet |
| Volume |
17 |
| Page |
1994-2005 |
| Year |
2008 |
|
PMID
|
|
|
| reference information 2 |
| |
Author
|
Morikawa, T., Kajimura, M., Nakamura, T., Hishiki, T., Nakanishi, T., Yukutake, Y., Nagahata, Y., Ishikawa, M., Hattori, K., Takenouchi, T., Takahashi, T., Ishii, I., Matsubara, K., Kabe, Y., Uchiyama, S., Nagata, E., Gadalla, M.M., Snyder, S.H., Suematsu, M. |
| Title |
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway. |
| Journal |
Proc Natl Acad Sci USA |
| Volume |
109 |
| Page |
1293-1298 |
| Year |
2012 |
|
PMID
|
|
|
| reference information 3 |
| |
Author
|
Nakano, S., Ishii, I., Shinmura, K., Tamaki, K., Hishiki, T., Akahoshi, N., Ida, T., Nakanishi, T., Kamata, S., Kumagai, Y., Akaike, T., Fukuda, K., Sano, M., Suematsu, M. |
| Title |
Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions. |
| Journal |
J Mol Med (Berl) |
| Volume |
93 |
| Page |
879-889 |
| Year |
2015 |
|
PMID
|
|
|
|
Disease , Applicable field information
|
| |
Disease name,
Applicable field
|
Osteosis, Hematology, Digestive Disorders, Metabolism, Neurobiology, Dermatology, Development, Pharmacology, Behavior, Physiology
|
|
|
