| |
CARD ID
 |
2253 |
| Type of strain |
Targeted mutant. |
| Strain name |
C57BL/6-Choptm1 |
| Internal Code |
Chop KO |
| Submitter |
Oike Yuich |
| Submitter affiliation or code |
- |
| Stock Type |
|
| Material Transfer Conditions |
It is necessary to consent to the submitter.
|
| Production method |
From other organizations.
|
Origin
(In-house) |
Organization |
|
| Organization code |
|
| Developer |
|
Origin
(From other organizations) |
Organization |
Osaka University |
| Organization code |
|
| Developer |
Shizuo Akira |
| Year introduced |
April
2000
|
Introduced
Generation |
20 |
| Remarks |
|
| |
Gene symbol
|
Ddit3 |
| Gene name |
DNA-damage inducible transcript 3 |
| Allele symbol |
Ddit3tm1 |
| Allele name |
DNA-damage inducible transcript 3, targeted mutation 1, |
| MGI |
MGI:109247 |
| Chromosome |
10 (10 D3 , 74.50) |
| Gene classification |
Targeted or trapped gene(knockout etc.) |
| Method |
Electroporation |
| OMIM |
|
|
| |
PCR Primer |
sCHOP1
|
cctggattaagcttggtagt
|
|
aCHOP5
|
ggacgcagggtcaagagtag
|
|
neo-F
|
agaggctattcggctatgac
|
|
neo-R
|
gcttgccgaatatcatggtg
|
|
| reference information 1 |
| |
Author
|
S. Oyadomari, A. Koizumi, K. Takeda, T. Gotoh, S. Akira, E. Araki & M. Mori. |
| Title |
A targeted disruption of the CHOP gene protects mice against ER stress-induced diabetes. |
| Journal |
J. Clin. Invest. |
| Volume |
109 |
| Page |
525-532 |
| Year |
2002 |
|
PMID
|
|
|
| reference information 2 |
| |
Author
|
H. Tsukano, T. Gotoh*, M. Endo, K. Miyata, H. Tazume, T. Kadomatsu, M. Yano, T. Iwawaki, K. Kohno, K. Araki, H. Mizuta & Y. Oike. |
| Title |
The Endoplasmic Reticulum Stress-CHOP Pathway-mediated Apoptosis in Macrophages Contributes to the Instability of Atherosclerotic Plaques. |
| Journal |
Arterioscler. Thromb. Vasc. Biol., |
| Volume |
30 |
| Page |
1925-1932 |
| Year |
2010 |
|
PMID
|
|
|
| reference information 3 |
| |
Author
|
Y. Miyazaki, K. Kaikita, M. Endo, E. Horio, M. Miura, K. Tsujita, S. Hokimoto, M. Yamamoto, T. Iwawaki, T. Gotoh, H. Ogawa & Y. Oike. |
| Title |
C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation. |
| Journal |
Arterioscler. Thromb. Vasc. Biol., |
| Volume |
31 |
| Page |
1124-1132 |
| Year |
2011 |
|
PMID
|
|
|
|
Disease , Applicable field information
|
| |
Disease name,
Applicable field
|
Hematology, Metabolism, Neurobiology, infectious, Diabetes, Cell biology
|
|
|
