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Strain Detail


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 Strain information
  CARD ID
1585 
Type of strain Targeted mutant. 
Strain name B6;129-Tnnt2tm2Mmto 
Internal Code B6;129-Tnnt2tm2Mmto 
Submitter Morimoto Sachio 
Submitter affiliation or code
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization Kyushu University 
Organization code
Developer Sachio Morimoto 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Tnnt2 
Gene name troponin T2, cardiac 
Allele symbol  
Allele name  
MGI MGI:104597 
Chromosome 1 (60.0) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
OMIM OMIM ID: 601494
Human Gene Symbol: CMD1D

 
 Primer 1
  PCR Primer TNT F2  5'CCT AAG CCC CAG ACC TAT GC 
TNT R2  5' GGT TCC TCC CCG TCC C 
 

 Reference information
 reference information 1
  Author
Du et al. 
Title Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation. 
Journal Circ. Res. 
Volume 101(2) 
Page 185-194 
Year 2007 
PMID  
 
 reference information 2
  Author
Sfichi-Duke et al. 
Title Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins. 
Journal J. Mol. Cell. Cardiol. 
Volume 48(5) 
Page 934-942 
Year 2010 
PMID  
 
 reference information 3
  Author
Zhan et al. 
Title Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation. 
Journal Cardiovasc. Res. 
Volume 84(1) 
Page 64-71 
Year 2009 
PMID  
 
 reference information 4
  Author
Wang et al. 
Title Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy. 
Journal Cardiovasc. Res. 
Volume 87(4) 
Page 636-646 
Year 2010 
PMID  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Hematology, Physiology 
  OMIM OMIM ID: 601494
Human Gene Symbol: CMD1D
Allelic Variant Name :
(Cardiomyopathy, Dilated, 1D)
Dilated cardiomyopathy