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Strain Detail

 - Strains   - Genes   - Reference   - Disease,Applicable field 
 Strain information
  CARD ID
 324 
Type of strain Spontaneous/Chemical induced mutant. 
Strain name B6EiC3H-a/A Egfrwa2 Wnt3avt 
Internal Code waved-2
B6EiC3H a/A-Egfrwa2Wnt3avt 
Submitter Unknown Unknown 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method From other organizations.
 
Origin
(In-house)		 Organization  
Organization code  
Developer  
Origin
(From other organizations)		 Organization The Jackson Laboratory 
Organization code  
Developer  
Year introduced August 2000  
Introduced 
Generation		  
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
 Wnt3a 
Gene name Wingless-related MMTV integration site 3A 
Allele symbol Wnt3avt 
Allele name Wnt3a, vestigial 
MGI MGI:98956 
Chromosome 11 (119.0cM) 
Gene classification Other gene(mutant etc.) 
Method  
GO
GO ID GO Term GO Evidence Code
GO:0001947 heart looping IMP
GO:0021874 Wnt receptor signaling pathway in forebrain neuroblast division IMP
GO:0021766 hippocampus development IMP
GO:0060070 Wnt receptor signaling pathway through beta-catenin IDA
GO:0048343 paraxial mesodermal cell fate commitment IMP
GO:0005576 extracellular region IEA
GO:0007275 multicellular organismal development IEA
GO:0016055 Wnt receptor signaling pathway IEA
GO:0005578 proteinaceous extracellular matrix IEA
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway IEA
more... (Total Hit Count: 25)
OMIM OMIM ID: 606359
Human Gene Symbol: WNT3A

GO
GO ID GO Term GO Evidence Code
GO:0001947 heart looping IMP
GO:0021874 Wnt receptor signaling pathway in forebrain neuroblast division IMP
GO:0021766 hippocampus development IMP
GO:0060070 Wnt receptor signaling pathway through beta-catenin IDA
GO:0048343 paraxial mesodermal cell fate commitment IMP
GO:0005576 extracellular region IEA
GO:0007275 multicellular organismal development IEA
GO:0016055 Wnt receptor signaling pathway IEA
GO:0005578 proteinaceous extracellular matrix IEA
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway IEA
more... (Total Hit Count: 25)
 
 Gene information 2
  Gene symbol
 Egfr 
Gene name Epidermal growth factor receptor 
Allele symbol Egfrwa2 
Allele name Egfr, waved 2 
MGI MGI:95294 
Chromosome 11 (119.0cM) 
Gene classification Other gene(mutant etc.) 
Method  
GO
GO ID GO Term GO Evidence Code
GO:0016021 integral to membrane IEA
GO:0016020 membrane IEA
GO:0005622 intracellular IDA
GO:0005886 plasma membrane IDA
GO:0016323 basolateral plasma membrane IDA
GO:0030139 endocytic vesicle IDA
GO:0004871 signal transducer activity IDA
GO:0046777 protein amino acid autophosphorylation IDA
GO:0050730 regulation of peptidyl-tyrosine phosphorylation IMP
GO:0000902 cell morphogenesis IGI
more... (Total Hit Count: 42)
OMIM OMIM ID: 131550
Human Gene Symbol: EGFR

GO
GO ID GO Term GO Evidence Code
GO:0016021 integral to membrane IEA
GO:0016020 membrane IEA
GO:0005622 intracellular IDA
GO:0005886 plasma membrane IDA
GO:0016323 basolateral plasma membrane IDA
GO:0030139 endocytic vesicle IDA
GO:0004871 signal transducer activity IDA
GO:0046777 protein amino acid autophosphorylation IDA
GO:0050730 regulation of peptidyl-tyrosine phosphorylation IMP
GO:0000902 cell morphogenesis IGI
more... (Total Hit Count: 42)
 
 Gene information 3
  Gene symbol
 a 
Gene name nonagouti 
Allele symbol A 
Allele name A, C3H allele 
MGI MGI:87853 
Chromosome 2  
Gene classification Other gene(mutant etc.) 
Method  
GO
GO ID GO Term GO Evidence Code
GO:0005576 extracellular region IEA
GO:0005515 protein binding IPI
GO:0009755 hormone-mediated signaling pathway IEA
GO:0006091 generation of precursor metabolites and energy IGI
GO:0008343 adult feeding behavior IMP, IGI
GO:0043473 pigmentation IMP
GO:0042438 melanin biosynthetic process IMP
GO:0032438 melanosome organization IMP
GO:0032402 melanosome transport IMP
GO:0031779 melanocortin receptor binding IPI
more... (Total Hit Count: 13)
OMIM OMIM ID: 600201
Human Gene Symbol: ASIP

GO
GO ID GO Term GO Evidence Code
GO:0005576 extracellular region IEA
GO:0005515 protein binding IPI
GO:0009755 hormone-mediated signaling pathway IEA
GO:0006091 generation of precursor metabolites and energy IGI
GO:0008343 adult feeding behavior IMP, IGI
GO:0043473 pigmentation IMP
GO:0042438 melanin biosynthetic process IMP
GO:0032438 melanosome organization IMP
GO:0032402 melanosome transport IMP
GO:0031779 melanocortin receptor binding IPI
more... (Total Hit Count: 13)
 
 Primer 1
  PCR Primer primerA  5'(TTGTG,GGTGG,CCTCC,TCTTC,ATAGTG)3' 
primerB  5'(AAACG,CCGAT,CTTCC,AGGTA,GTTCA,TGCC)3' 
 

 Reference information
 reference information 1
  Author
 KERRY J. FOWLER, FRANCESCA WALKER, WARREN ALEXANDER, MARGARET L. HIBBS, EDOUARD C. NICE, RALPH M. BOHMER, G. BRUCE MANN, CASSANDRA THUMWOOD, ROSEMARIE MAGLITTO, JANINE A. DANKS, RUNJEN CHETTY, ANTONY W. BURGESS, AND ASHLEY R. DUNN 
Title A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation 
Journal Proc. Natl. Acad. Sci. USA 
Volume 92 
Page 1465-1469 
Year 1995 
PMID 7533293  
 
 Disease , Applicable field information
  OMIM OMIM ID: 606359
Human Gene Symbol: WNT3A

OMIM ID: 131550
Human Gene Symbol: EGFR
Allelic Variant Name :
•
NONSMALL CELL LUNG CANCER, RESISTANCE TO TYROSINE KINASE INHIBITOR
•
NONSMALL CELL LUNG CANCER, RESPONSE TO TYROSINE KINASE INHIBITOR IN,

OMIM ID: 600201
Human Gene Symbol: ASIP
Allelic Variant Name :
•
SKIN/HAIR/EYE PIGMENTATION 9, DARK/LIGHT HAIR

 
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