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Strain Detail

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Strain information

	CARD ID		2270
	Type of strain		Targeted mutant.
	Strain name		B6;129-DSCR-1^tm1ApoE^tm1
	Internal Code		DSCR-1, ApoE double knockout mouse
	Submitter		Minami Takashi
	Submitter affiliation or code		Labs for Vascular Biology RCAST, The University of Tokyo
	Stock Type
	Material Transfer Conditions		It is necessary to consent to the submitter.
	Production method		In-house breading.
	Origin (In-house)	Organization	RCAST, The Univ. of Tokyo
		Organization code	RAC10113
		Developer	Takashi Minami
	Origin (From other organizations)	Organization	Harvard Univ. Medical School
		Organization code	•s–¾
		Developer	Juda Folkman, Sandra Ryeom
		Year introduced	June 2008
		Introduced Generation
	Remarks

Gene information

Gene information 1

	Gene symbol		RCAN1
	Gene name		regulator of calcineurin 1
	Allele symbol		RCAN1^tm1
	Allele name		regulator of calcineurin 1, targeted mutation 1,
	MGI		MGI:1890564
	Chromosome		16 (53.60)
	Gene classification		Targeted or trapped gene(knockout etc.)
	Method		Electroporation
	OMIM

Gene information 2

	Gene symbol		Apoe
	Gene name		apolipoprotein E
	Allele symbol		Apoe^tm1
	Allele name		apolipoprotein E, targeted mutation 1,
	MGI		MGI:88057
	Chromosome		7 (9.94)
	Gene classification		Targeted or trapped gene(knockout etc.)
	Method
	OMIM

Reference information

reference information 1

	Author	Sandra Ryeom, Kwan-Hyuck Baek, Matthew J. Rioth, Ryan C. Lynch, Alexander Zaslavsky, Amy Birsner, Sam S. Yoon, and Frank McKeon
	Title	Targeted Deletion of the Calcineurin Inhibitor DSCR1 Suppresses Tumor Growth
	Journal	Cancer Cell
	Volume	13
	Page	420-431
	Year	2008
	PMID

Disease , Applicable field information

Disease name,
Applicable field

Metabolism, cancer, Anatomy, Physiology