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Strain Detail

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Strain information

	CARD ID		136
	Type of strain		Targeted mutant.
	Strain name		B10.129(B6)SnJ-Rag2^tm1Fwa
	Internal Code		B10.129(B6)SnJ-Rag2^tm1 N12
	Submitter		Shigeo Koyasu
	Submitter affiliation or code		RIKEN
	Stock Type
	Material Transfer Conditions		It is necessary to consent to the submitter.
	Production method		From other organizations.
	Origin (In-house)	Organization
		Organization code
		Developer
	Origin (From other organizations)	Organization	Columbia Univ. (Shinkai & Alt)
		Organization code	Fwa
		Developer
		Year introduced	1993
		Introduced Generation
	Remarks

Gene information

Gene information 1

	Gene symbol		Rag2
	Gene name		Recombination-activating gene 2
	Allele symbol
	Allele name
	MGI		MGI:97849
	Chromosome		2 (56.0cM)
	Gene classification		Targeted or trapped gene(knockout etc.)
	Method		Other
	OMIM		OMIM ID: 179616 Human Gene Symbol: RAG2

Reference information

reference information 1

	Author	Yoichi Shinkai, Gary Rathbun, Kong-Peng Lam, Eugene M. Oltz, Valerie Stewart, Monica Mendelsohn, Jean Charron, Milton Datta, Faith Young, Alan M. Stall, and Frederick W. Alt
	Title	RAG-2-Deficient Mice Lack Mature Lymphocytes Owing to Inability to Initiate V(D)J Rearrangement
	Journal	Cell
	Volume	68
	Page	855-867
	Year	1992
	PMID	1547487

Disease , Applicable field information

OMIM

OMIM ID: 179616
Human Gene Symbol: RAG2
Allelic Variant Name :

•	SEVERE COMBINED IMMUNODEFICIENCY, B CELL-NEGATIVE
•	OMENN SYNDROME
•	COMBINED CELLULAR AND HUMORAL IMMUNE DEFECTS WITH GRANULOMAS