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Strain Detail


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 Strain information
  CARD ID
136 
Type of strain Targeted mutant. 
Strain name B10.129(B6)SnJ-Rag2tm1Fwa 
Internal Code
B10.129(B6)SnJ-Rag2tm1 N12 
Submitter Shigeo Koyasu 
Submitter affiliation or code RIKEN 
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method From other organizations.
 
Origin
(In-house)
Organization  
Organization code  
Developer  
Origin
(From other organizations)
Organization Columbia Univ. (Shinkai & Alt) 
Organization code Fwa 
Developer  
Year introduced 1993  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Rag2 
Gene name Recombination-activating gene 2 
Allele symbol  
Allele name  
MGI MGI:97849 
Chromosome 2 (56.0cM) 
Gene classification Targeted or trapped gene(knockout etc.) 
Method Other 
OMIM OMIM ID: 179616
Human Gene Symbol: RAG2

 

 Reference information
 reference information 1
  Author
Yoichi Shinkai, Gary Rathbun, Kong-Peng Lam, Eugene M. Oltz, Valerie Stewart, Monica Mendelsohn, Jean Charron, Milton Datta, Faith Young, Alan M. Stall, and Frederick W. Alt 
Title RAG-2-Deficient Mice Lack Mature Lymphocytes Owing to Inability to Initiate V(D)J Rearrangement 
Journal Cell 
Volume 68 
Page 855-867 
Year 1992 
PMID 1547487  
 
 Disease , Applicable field information
  OMIM OMIM ID: 179616
Human Gene Symbol: RAG2
Allelic Variant Name :
SEVERE COMBINED IMMUNODEFICIENCY, B CELL-NEGATIVE
OMENN SYNDROME
COMBINED CELLULAR AND HUMORAL IMMUNE DEFECTS WITH GRANULOMAS