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Strain Detail


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 Strain information
  CARD ID
365 
Type of strain Targeted mutant. 
Strain name B6;129X1-Adra1btm1 
Internal Code B6/129sv-α1BD-AR-KO 
Submitter Unknown Unknown 
Submitter affiliation or code  
Stock Type  
Material Transfer Conditions It is necessary to consent to the submitter. 
 
Production method In-house breading.
 
Origin
(In-house)
Organization  
Organization code unknown 
Developer Tanoue Akito 
Origin
(From other organizations)
Organization  
Organization code  
Developer  
Year introduced  
Introduced 
Generation
 
Remarks  
 
 Gene information
 Gene information 1
  Gene symbol
Adra1b 
Gene name Adrenergic receptor, alpha 1b 
Allele symbol Adra1btm1 
Allele name Adra1b, targeted mutation 1 
MGI MGI:104774 
Chromosome 11  
Gene classification Targeted or trapped gene(knockout etc.) 
Method Electroporation 
GO
GO ID GO Term GO Evidence Code
GO:0004871 signal transducer activity IEA
GO:0043278 response to morphine IMP
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IGI
GO:0008542 visual learning IMP
GO:0001975 response to amphetamine IMP
GO:0007626 locomotory behavior IMP
GO:0000299 integral to membrane of membrane fraction IDA
GO:0004930 G-protein coupled receptor activity IEA
GO:0007186 G-protein coupled receptor protein signaling pathway IEA
more... (Total Hit Count: 29)
OMIM OMIM ID: 104220
Human Gene Symbol: ADRA1B

GO
GO ID GO Term GO Evidence Code
GO:0004871 signal transducer activity IEA
GO:0043278 response to morphine IMP
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IGI
GO:0008542 visual learning IMP
GO:0001975 response to amphetamine IMP
GO:0007626 locomotory behavior IMP
GO:0000299 integral to membrane of membrane fraction IDA
GO:0004930 G-protein coupled receptor activity IEA
GO:0007186 G-protein coupled receptor protein signaling pathway IEA
more... (Total Hit Count: 29)
 
 Primer 1
  PCR Primer primerA  2.C alpha1D: (1)PCR primer A 5'(ACACA,GCTGC,ACTCA,GTAGC,AGGTC,A)3'
alpha1B: (1)PCR primer A 5'(CCTGC,AGGTA,TGAGG,CTCTG,T)3' 
primerB  2.C alpha1D: (2)PCR primer B 5'(CCTAC,ATTTT,GAATG,GAAGG,ATTG)3'
alpha1B: (2)PCR primer B 5'(ATTTG,TCACG,TCCTG,CACGA,C)3' 
 

 Reference information
 reference information 1
  Author
Akito Tanoue, Yoshihisa Nasa, Takaaki Koshimizu, Hitomi Shinoura, Sayuri Oshikawa, Takayuki Kawai, Sachie Sunada, Satoshi Takeo, and Gozoh Tsujimoto 
Title The α1D-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction 
Journal The Journal of Clinical Investigation 
Volume 109 
Page 765-775 
Year 2002 
PMID 11901185  
 
 reference information 2
  Author
ANTONELLA CAVALLI, ANNE-LAURE LATTION, EDITH HUMMLER, MONIQUE NENNIGER, THIERRY PEDRAZZINI, JEAN-FRANCOIS AUBERT, MARTIN C. MICHEL, MING YANG, GIUSEPPE LEMBO, CARMINE VECCHIONE, MARINA MOSTARDINI, ANDREA SCHMIDT, FRIEDRICH BEERMANN, AND SUSANNA COTECCHIA 
Title Decreased blood pressure response in mice deficient of the α1b-adrenergic receptor 
Journal Proc. Natl. Acad. Sci. USA 
Volume 94 
Page 11589-11594 
Year 1997 
PMID 9326654  
 
 Disease , Applicable field information
  Disease name,
Applicable field
Physiology 
  OMIM OMIM ID: 104220
Human Gene Symbol: ADRA1B