| |
CARD ID
 |
2095 |
| Type of strain |
Targeted mutant. |
| Strain name |
B6;129-Deddtm1Timy |
| Internal Code |
DEDD KO |
| Submitter |
Miyazaki Toru |
| Submitter affiliation or code |
Lab of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine (CDBIM), The University of Tokyo |
| Stock Type |
|
| Material Transfer Conditions |
It is necessary to consent to the submitter.
|
| Production method |
In-house breading.
|
Origin
(In-house) |
Organization |
The University of Tokyo |
| Organization code |
|
| Developer |
Toru Miyazaki |
Origin
(From other organizations) |
Organization |
|
| Organization code |
|
| Developer |
|
| Year introduced |
|
Introduced
Generation |
|
| Remarks |
|
| |
Gene symbol
|
Dedd |
| Gene name |
death effector domain-containing |
| Allele symbol |
Deddtm1Timy |
| Allele name |
death effector domain-containing, targeted mutation 1, Toru Miyazaki |
| MGI |
MGI:1333874 |
| Chromosome |
1 (1H2 , 79.34) |
| Gene classification |
Targeted or trapped gene(knockout etc.) |
| Method |
Electroporation |
| OMIM |
|
|
| |
PCR Primer |
D5-1
|
ATG GCG GGC CTA AAG AGG CGG GCA
|
|
D3-1
|
CTC GTC TCT TCT TGA GAG TAA CGT
|
|
| |
PCR Primer |
TM-1
|
CAG CCA GAT TTA CAT AGT GAA ATC
|
|
NY-5
|
CCG CTA TCA GGA CAT AGC GTT GGC
|
|
| reference information 1 |
| |
Author
|
Arai S, Miyake K, Voit R, Nemoto S, Wakeland EK, Grummt I, Miyazaki T |
| Title |
Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1. |
| Journal |
Proc Natl Acad Sci U S A. |
| Volume |
104 |
| Page |
2289-94 |
| Year |
2007 |
|
PMID
|
|
|
| reference information 2 |
| |
Author
|
Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T. |
| Title |
The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation. |
| Journal |
J Biol Chem |
| Volume |
284 |
| Page |
5050-5 |
| Year |
2009 |
|
PMID
|
|
|
| reference information 3 |
| |
Author
|
Kurabe N, Mori M, Kurokawa J, Taniguchi K, Aoyama H, Atsuda K, Nishijima A, Odawara N, Harada S, Nakashima K, Arai S, Miyazaki T |
| Title |
The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability. |
| Journal |
Biochem Biophys Res Commun |
| Volume |
39 |
| Page |
1708-13 |
| Year |
2009 |
|
PMID
|
|
|
| reference information 4 |
| |
Author
|
Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S, Miyazaki T |
| Title |
Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. |
| Journal |
J Clin Invest |
| Volume |
121 |
| Page |
318-27 |
| Year |
2011 |
|
PMID
|
|
|
|
Disease , Applicable field information
|
| |
Disease name,
Applicable field
|
Reproduction, cancer, Cell biology, Molecular biology
|
|
|
