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Strain Detail

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Strain information

	CARD ID		92
	Type of strain		Targeted mutant.
	Strain name		C57BL/6-Rag1^tm2(GFP)Imku
	Internal Code		RAG 1 knockin mice 86
	Submitter		Nobuo SAKAGUCHI
	Submitter affiliation or code		Kumamoto University School of Medicine, Department of Immunoloy
	Stock Type
	Material Transfer Conditions		Other conditions.
	Production method		In-house breading.
	Origin (In-house)	Organization	Imku
		Organization code	Imku
		Developer	Nobuo Sakaguchi
	Origin (From other organizations)	Organization
		Organization code
		Developer
		Year introduced
		Introduced Generation
	Remarks

Gene information

Gene information 1

	Gene symbol		Rag1
	Gene name		Recombination-activating gene 1
	Allele symbol
	Allele name
	MGI		MGI:97848
	Chromosome		2 (56.0cM)
	Gene classification		Targeted or trapped gene(knockout etc.)
	Method		Other
	OMIM		OMIM ID: 179615 Human Gene Symbol: RAG1

Gene information 2

	Gene symbol		GFP
	Gene name		Green Fluorescence Protein
	Allele symbol
	Allele name
	MGI
	Chromosome
	Gene classification		Targeted or trapped gene(knockout etc.)
	Method		Other
	OMIM

Reference information

reference information 1

	Author	Naomi Kuwata, Hideya Igarashi, Takafumi Ohmura, Shinichi Aizawa, and Nobuo Sakaguchi
	Title	Cutting Edge: Absence of Expression of RAG1 in Peritoneal B-1 Cells Detected by Knocking into RAG1 Locus with Green Fluorescent Protein Gene
	Journal	The Journal of Immunology
	Volume	163
	Page	6355-6359
	Year	1999
	PMID	10586023

Disease , Applicable field information

OMIM

OMIM ID: 179615
Human Gene Symbol: RAG1
Allelic Variant Name :

•	RECOMBINATION ACTIVATING GENE 1 POLYMORPHISM
•	COMBINED CELLULAR AND HUMORAL IMMUNE DEFECTS WITH GRANULOMAS
•	ALPHA/BETA T-CELL LYMPHOPENIA WITH GAMMA/DELTA T-CELL EXPANSION, SEVERE
•	OMENN SYNDROME
•	SEVERE COMBINED IMMUNODEFICIENCY, B CELL-NEGATIVE