| |
CARD ID
 |
88 |
| Type of strain |
Targeted mutant. |
| Strain name |
C57BL/6-Rag1tm1(GFP)Imku |
| Internal Code |
RAG 1 knock-in mouse |
| Submitter |
Nobuo SAKAGUCHI |
| Submitter affiliation or code |
Kumamoto University School of Medicine, Department of Immunoloy |
| Stock Type |
|
| Material Transfer Conditions |
Other conditions.
|
| Production method |
In-house breading.
|
Origin
(In-house) |
Organization |
Imku |
| Organization code |
Imku |
| Developer |
Nobuo Sakaguchi |
Origin
(From other organizations) |
Organization |
|
| Organization code |
|
| Developer |
|
| Year introduced |
|
Introduced
Generation |
|
| Remarks |
|
| |
Gene symbol
|
GFP |
| Gene name |
Green Fluorescence Protein |
| Allele symbol |
|
| Allele name |
|
| MGI |
|
| Chromosome |
|
| Gene classification |
Targeted or trapped gene(knockout etc.) |
| Method |
Other |
| OMIM |
|
|
| |
Gene symbol
|
Rag1 |
| Gene name |
Recombination-activating gene 1 |
| Allele symbol |
|
| Allele name |
|
| MGI |
MGI:97848 |
| Chromosome |
2 (56.0cM) |
| Gene classification |
Targeted or trapped gene(knockout etc.) |
| Method |
Other |
| OMIM |
OMIM ID:
179615
Human Gene Symbol:
RAG1
|
|
| reference information 1 |
| |
Author
|
Robert C. Rickert, Jurgen Roes and Klaus Rajewsky |
| Title |
B Iymphocyte-specific, Cre-mediated mutagenesis in mice |
| Journal |
Nucleic Acids Research |
| Volume |
25 |
| Page |
1317-1318 |
| Year |
1997 |
|
PMID
|
9092650
|
|
| reference information 2 |
| |
Author
|
Yousuke Takahama, Kazuhito Ohishi, Yayoi Tokoro, Takehiko Sugawara, Yasuhide Yoshimura, Masaru Okabe, Taroh Kinoshita and Junji Takeda |
| Title |
Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene |
| Journal |
Eur. J. Immunol. |
| Volume |
28 |
| Page |
2159-2166 |
| Year |
1998 |
|
PMID
|
9692885
|
|
| reference information 3 |
| |
Author
|
Naomi Kuwata, Hideya Igarashi, Takafumi Ohmura, Shinichi Aizawa, and Nobuo Sakaguchi |
| Title |
Cutting Edge: Absence of Expression of RAG1 in Peritoneal B-1 Cells Detected by Knocking into RAG1 Locus with Green Fluorescent Protein Gene |
| Journal |
The Journal of Immunology |
| Volume |
163 |
| Page |
6355-6359 |
| Year |
1999 |
|
PMID
|
10586023
|
|
| reference information 4 |
| |
Author
|
Araki, K., Araki, M., Miyazaki, J. & Vassalli, P. |
| Title |
Site-Specific Recombination of a Transgene in Fertilized Eggs by Transient Expression of Cre Recombinase |
| Journal |
Proc. Natl. Acad. Sci. USA |
| Volume |
92 |
| Page |
160-164 |
| Year |
1995 |
|
PMID
|
7816809
|
|
|
Disease , Applicable field information
|
| |
OMIM |
OMIM ID:
179615
Human Gene Symbol:
RAG1
Allelic Variant Name :
| • |
SEVERE COMBINED IMMUNODEFICIENCY, B CELL-NEGATIVE |
| • |
COMBINED CELLULAR AND HUMORAL IMMUNE DEFECTS WITH GRANULOMAS |
| • |
OMENN SYNDROME |
| • |
ALPHA/BETA T-CELL LYMPHOPENIA WITH GAMMA/DELTA T-CELL EXPANSION, SEVERE |
| • |
RECOMBINATION ACTIVATING GENE 1 POLYMORPHISM |
|
|
|
